Profa. Dra. Renata Frazão


Research interests

Neural pathways that modulate reproduction.


In the neuroendocrine control of the ovulatory cycle is very well known that the LH surge is an event that occurs at specific time of the day. The preovulatory LH surge is initiated on the day of proestrus when estrogen levels are high. Several evidences implicate that environmental clues in association to estrogen levels, and others hormones as prolactin, are responsible for the synchronization of the ovulatory cycle. However, it is still a mystery how such kind of information can be integrated. Our laboratory uses electrophysiological and neuroanatomical tools to investigate the contribution of different hypothalamic neuronal groups, as well as the effects of different neurotransmitters (eg, vasopressin, VIP, etc.) or hormones (eg, leptin, prolactin, etc) onto specific populations to modulate the ovulatory cycle and reproduction.

Main publications

  • Clarke JR, Lyra E Silva NM, Figueiredo CP, Frozza RL, Ledo JH, Beckman D, Katashima CK, Razolli D, Carvalho BM, Frazão R, Silveira MA, Ribeiro FC, Bomfim TR, Neves FS, Klein WL,Medeiros R, LaFerla FM, Carvalheira JB, Saad MJ, Munoz DP, Velloso LA, Ferreira ST, De Felice FG. Alzheimer-associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation. EMBO Mol Med. v. 7(2), p. 190-210, 2015.
  • Silva, R.P; Zampieri, T.T; Pedroso, A.B.J; Nagaishi, V.S; Lobo, A.M.R; Furigo, I.C; Frazão, R; Donato, J. Jr. Leptin resistance is not the primary cause of weight gain associated with reduced sex hormone levels in female mice. Endocrinology. v. 155(11), p. 4226-36, 2014.
  • Frazão, R; Dungan Lemko, HM; Ratra, DV; Lee, C; Williams, KW; Zigman JM; Elias , CF. Estrogen Induces Ghrelin Receptor Expression in Kiss1 Neurons. American Journal of Physiology Endocrinology and Metabolism. 306(6): E606-614, 2014.
  • Frazão, R; Cravo, R, M; Donato, J Jr; Clegg, D; Elmquist, J; Zigman, J, M; Williams, K, W; Eias, C, F. Shift in Kiss1 cell activity requires estrogen receptor α. J. Neuroscience. v.14 (3), p. 301-312, 2013.
  • Cravo, R. M., and Frazão, R; Perello1, M; Osborne-Lawrence1, S; Williams, K. W; Zigman, J. M; Vianna, C; Elias, C. F. Leptin signaling in Kiss1 neurons arises after pubertal development. Plos One.v. 8(3), p. 1-7, 2013.
  • Ramadori, G; Fujiwawa, T; Anderson, J; Berflund, E; Frazão, R; Michan, S; Vianna, c; Sinclair, D; Elias, C; Coppari, R. SIRT1 Deacetylase in SF1 neurons protects against metabolic imbalance. Cell Metabolism. v. 14, p. 301-312, 2011.
  • Frazão, R; McMahon, D, G; Schunack, W; Datta, P; Heidelberger, R; Marshak, D, W. Histamine elevates free intracellular calcium in mouse retinal dopaminergic cells via H1-receptors.  IOVS, v. 52, p. 3083-3088, 2011.
  • Donato J Jr, Cravo RM, Frazão, R; Gautron L, Scott MM, Lachey J, Margatho LO, Lee S, Lee C, Richardson JA, Friedman J, Chua S Jr, Coppari R, Zigman, J.M; Elmquist JK, Elias CF. Leptin’s effect on puberty in mice is relayed by the ventral premammillary nucleus and does not require signaling in Kiss1 neurons. The Journal of Clinical Investigation. v. 121, p355-368, 2011.
  • Cravo, R; Margatho, L,O.; Osborne-Lawrence, S.; Donato Jr. J.; Atkin, S.; Bookout, A. L.; Rovinsky, S.; Frazão, R.; Lee, C.E.; Gautron, L.; Zigman, J.; Elias, C. F.  Characterization of Kiss1 neurons using transgenic mouse modelsNeuroscience, v. 173, p. 37-56, 2011.