Profa. Dra. Gabriela Placoná Diniz

  • Professora Doutora (RDIDP)
  • Laboratório de Biologia Celular e Anatomia Funcional (LBCAF), Depto Anatomia – ICB III / USP
  • Telefone: 55 (11) 3091-7750
  • Fax: 55 (11) 3091-7366
  • E-mail: gpdiniz@usp.br
  • Currículo Lattes:  

Linha de pesquisa

Papel dos miRNAs nas alterações cardiovasculares induzidas pela dieta rica em gordura.

Descrição

Avaliar a participação de miRNA e de outras vias moleculares no remodelamento cardíaco induzido pela dieta rica em gordura

Principais trabalhos publicados

  • Takano AP, Diniz GP, Barreto-Chaves ML. AMPK signaling pathway is rapidly activated by T3 and regulates the cardiomyocyte growth. Mol Cell Endocrinol. 2013 Aug 25;376(1-2):43-50. doi: 10.1016/j.mce.2013.05.024. Epub 2013 Jun 6.
  • Diniz GP, Takano AP, Barreto-Chaves ML. miRNA-208a and miRNA-208b are triggered in thyroid hormone-induced cardiac hypertrophy – role of type 1 Angiotensin II receptor (AT1R) on miRNA-208a/a-MHC modulation. Mol Cell Endocrinol. 2013 Jul 15;374(1-2):117-24. doi: 10.1016/j.mce.2013.04.010. Epub 2013 Apr 26.
  • Diniz GP, Takano AP, Bruneto E, Silva FG, Nunes MT, Barreto-Chaves ML. New insight into the mechanisms associated with the rapid effect of T₃ on AT1R expression. J Mol Endocrinol. 2012 May 30;49(1):11-20. doi: 10.1530/JME-11-0141. Print 2012 Aug
  • Araujo AS, Diniz GP, Seibel FE, Branchini G, Ribeiro MF, Brum IS, Khaper N, Barreto-Chaves ML, Belló-Klein A. Reactive oxygen and nitrogen species balance in the determination of thyroid hormones-induced cardiac hypertrophy mediated by renin-angiotensin system. Mol Cell Endocrinol. 2011 Feb 10;333(1):78-84. doi: 10.1016/j.mce.2010.12.018. Epub 2010 Dec 17.
  • Carneiro-Ramos MS, Diniz GP, Nadu AP, Almeida J, Vieira RL, Santos RA, Barreto-Chaves ML. Blockage of angiotensin II type 2 receptor prevents thyroxine-mediated cardiac hypertrophy by blocking Akt activation. Basic Res Cardiol. 2010 May;105(3):325-35. doi: 10.1007/s00395-010-0089-0. Epub 2010 Feb 14.
  • Diniz GP, Carneiro-Ramos MS, Barreto-Chaves ML. Angiotensin type 1 receptor mediates thyroid hormone-induced cardiomyocyte hypertrophy through the Akt/GSK-3beta/mTOR signaling pathway. Basic Res Cardiol. 2009 Nov;104(6):653-67. doi: 10.1007/s00395-009-0043-1. Epub 2009 Jul 9.
  • Carneiro-Ramos MS, Diniz GP, Almeida J, Vieira RL, Pinheiro SV, Santos RA, Barreto-Chaves ML. Cardiac angiotensin II type I and type II receptors are increased in rats submitted to experimental hypothyroidism. J Physiol. 2007 Aug 15;583(Pt 1):213-23. Epub 2007 May 31.
  • Diniz GP, Carneiro-Ramos MS, Barreto-Chaves ML. Angiotensin type 1 (AT1) and type 2 (AT2) receptors mediate the increase in TGF-beta1 in thyroid hormone-induced cardiac hypertrophy. Pflugers Arch. 2007 Apr;454(1):75-81. Epub 2007 Jan 6.