Profa. Dra. Camila Squarzoni Dale

  • Professor Doutor (RDIDP)
  • Laboratório de Neuromodulação da Dor – ICB III / USP
  • Telefone: 55 (11) 3091-7768 / 8452
  • Fax: 55(11)-3091-8449
  • E-mail: camila.dale@usp.br
  • Currículo Lattes: 

Linhas de pesquisa

Neuromodulação da Dor

Descrição

Neuromodulação da dor, com ênfase na fisiopatologia envolvida nas vias de sinalização relacionadas à analgesia induzida pela estimulação elétrica encefálica, na busca de novos alvos para o tratamento de dor refratária e no estudo da ação de neuropepetídeos como ferramentas terapêuticas para o tratamento da dor.

Principais trabalhos publicados

  • Fogaça MV, Sonego A, Rioli V, Gozzo F, Dale CS, ferro ES, Guimarães F.  Anxiogenic-like effects induced by hemopressin in rats. Pharmacology, Biochemistry and Behavior, v. 129: 7-13, 2015.
  • Toniolo EF, Maique ET, Ferreira WA, Heimann AS, Ferro ES, Ramos-Ortolaza DL, Miller L, Devi LA, Dale CS. Hemopressin, an inverse agonist of cannabinoid receptors, inhibits neuropathic pain in rats. Peptides (New York, N.Y. 1980), v. 56, p. 125-131, 2014.
  • Nadur-Andrade N, Zamuner SR, Toniolo EF, de Lima CJ, Cogo JC, Dale CS. Analgesic Effect of Light-Emitting Diode (Led) Therapy At Wavelengths Of 635 And 945 Nm On Bothrops Moojeni Venom-Induced Hyperalgesia. Photochem Photobiol. 13: 1561-1567, 2014.
  • Ribeiro NM, Toniolo EF, Castro LM, Russo LC, Rioli V, Ferro ES, Dale CS. AGH is a new hemoglobin alpha-chain fragment with antinociceptive activity. Peptides. ;48:10-20, 2013.
  • França NR, Toniolo EF, Franciosi AC, Alves AS, de Andrade DC, Fonoff ET, Britto LR, Dale CS. Antinociception induced by motor cortex stimulation: somatotopy of behavioral response and profile of neuronal activation. Behav Brain Res. 250:211-21, 2013.
  • Pagano RL,  Fonoff ET, Dale CS, Ballester G, Teixeira MJ, Britto LRG. Motor cortex stimulation inhibits thalamic sensory neurons and enhances activity of PAG neurons: possible pathways for antinociception. Pain, 153(12):2359-69, 2012.
  • Souza LG, Dale CS, Nadur-Andrade N, Cogo JC, Zamuner SR. Low Level Laser Therapy reduces edema, leukocyte influx and hyperalgesia induced by Bothrops jararacussu snake venom. Clin Exp Med Letters 52:97-102, 2011.
  • Pagano RL, Assis DV, Clara JÁ, Alves AS, Dale CS, Teixeira MJ, Fonoff ET, Britto LRG “Transdural motor cortex stimulation reverses neuropathic pain in rats: A profile of neuronal activation” European Journal of Pain 15:268.e1-268.e14, 2011.
  • Gomes I, Dale CS, Casten K, Geigner MA, Gozzo FC, Ferro ES, Heimann AS, Devi LA “Hemoglobin-derived peptides as novel type of bioactive signaling molecules” AAPS Journal 12: 658-669, 2010.
  • Dale CS, Altier C, Cenac N, Giorgi R, Juliano MA, Juliano L, Zamponi GW, Vergnolle N. “Analgesic properties of S100A9 C-terminal domain: a mechanism dependent on calcium channel inhibition”, Fundam Clin Pharmacol. 23(4):427-38, 2009.
  • Fonoff ET, Pereira JF Jr, Camargo LV, Dale CS, Pagano RL, Ballester G, Teixeira MJ. “Functional mapping of the motor cortex of the rat using transdural electrical stimulation”, Behav Brain Res. 202(1):138-41, 2009
  • Fonoff ET, Dale CS, Pagano RL, Paccola CC, Ballester G, Teixeira MJ, Giorgi R. “Antinociception induced by epidural motor cortex stimulation in naive conscious rats is mediated by the opioid system”,  Behav Brain Res. 196(1):63-70, 2009
  • Dale CS, Vergnolle N. “Protease signaling to G protein-coupled receptors: implications for inflammation and pain”, Journal ofReceptors and Signal Transduction, 28:29-37, 2008
  • Heimann AS, Gomes I, Dale CS, Pagano RL, Gupta A, Souza LL, Luchesi AD, Castro LM, Girogi R, Rioli V, Ferro ES, Devi LA. “Hempressin is an inverse agonist of CB1 cannabinoid receptors”, Proceedings of the National Academy of Sciences – PNAS, 104:20588-93, 2007
  • Altier C, Dale CS, Kisilevsky AE, Chapman K, Castiglioni AJ, Matthews EA, Evans RM, Dickenson AH, Lipscombe D, Vergnolle N, Zamponi GW. “Differential role of N-type calcium channel splice isoforms in pain”, The Journal of Neuroscience, 27(24):6363-73, 2007
  • Dale CS, Cenac N, Britto LR, Juliano MA, Juliano L, Vergnolle N, Giorgi R. “The C-terminus of murine S100A9 protein inhibits hyperalgesia induced by the agonist peptide of protease-activated receptor 2 (PAR2)”, British Journal of Pharmacology, 149(4):374-84, 2006
  • Dale CS, Pagano Rde L, Paccola CC, Pinotti-Guirao T, Juliano MA, Juliano L, Giorgi R. “Effect of the C-terminus of murine S100A9 protein on experimental nociception”, Peptides, 27(11):2794-802, 2006
  • Dale CS, Pagano Rde L, Rioli V, Hyslop S, Giorgi R, Ferro ES. “Antinociceptive action of hemopressin in experimental hyperalgesia”, Peptides, Mar;26(3):431-6, 2005